| Date | Opponent | Time/TV | Tickets | |
| Sunday Sept. 4, 2016 |  | Texas Longhorns Darrell K Royal – TX Mem. Stadium, Austin, TX | 7:30 PM ET | Lost 50-47 2OT |
| Saturday Sept. 10, 2016 |  | Nevada Wolf Pack Notre Dame Stadium, South Bend, IN | 3:30 PM ET | Won 39-10 |
| Saturday Sept. 17, 2016 |  | Michigan State Spartans Notre Dame Stadium, South Bend, IN | 7:30 PM ET | Lost 36-28 |
| Saturday Sept. 24, 2016 |  | Duke Blue Devils Notre Dame Stadium, South Bend, IN | 3:30 PM ET | Lost 38-35 |
| Saturday Oct. 1, 2016 |  | Syracuse Orange MetLife Stadium, East Rutherford, NJ | 12:00 PM ET | Won 50-33 |
| Saturday Oct. 8, 2016 |  | NC State Wolfpack Carter-Finley Stadium, Raleigh, NC | 12:00 PM ET ABC | Lost 10-3 |
| Saturday Oct. 15, 2016 |  | Stanford Cardinal Notre Dame Stadium, South Bend, IN | 7:30 PM ET | Lost 17-10 |
| Saturday Oct. 22, 2016 | Bye Week | |||
| Saturday Oct. 29, 2016 |  | Miami Hurricanes Notre Dame Stadium, South Bend, IN | 3:30 PM ET | Won 30-27 |
| Saturday Nov. 5, 2016 |  | Navy Midshipmen EverBank Field, Jacksonville, FL | 11:30 AM ET | Lost 28-27 |
| Saturday Nov. 12, 2016 |  | Army Black Knights Alamodome, San Antonio, TX | 3:30 PM ET | Won 44-6 |
| Saturday Nov. 19, 2016 |  | Virginia Tech Hokies Notre Dame Stadium, South Bend, IN | 3:30 PM ET | Lost 34-31 |
| Saturday Nov. 26, 2016 |  | USC Trojans L.A. Memorial Coliseum, Los Angeles, CA | 3:30 PM ET | Lost 45-27 |
