| Date | Opponent | Time/TV | Tickets | |
| Saturday Sep 12, 2020 |  | Duke Blue Devils Notre Dame Stadium, South Bend, IN | 2:30 PM ET NBC | Won 27-13 |
| Saturday Sep 19, 2020 |  | USF Bulls Notre Dame Stadium, South Bend, IN | 2:30 PM ET USA Network | Won 52-0 |
| Saturday Sep 26, 2020 | Bye Week | |||
| Saturday Oct 3, 2020 | Bye Week | |||
| Saturday Oct 10, 2020 |  | Florida State Seminoles Notre Dame Stadium, South Bend, IN | 7:30 PM ET NBC | Won 42-26 |
| Saturday Oct 17, 2020 |  | Louisville Cardinals Notre Dame Stadium, South Bend, IN | 2:30 PM ET NBC | Won 12-7 |
| Saturday Oct 24, 2020 |  | at Pitt Panthers Heinz Field, Pittsburgh, PA | 3:30 PM ET ABC | Won 45-3 |
| Saturday Oct 31, 2020 |  | at Georgia Tech Yellow Jackets Bobby Dodd Stadium, Atlanta, GA | 3:30 PM ET ABC | Won 31-13 |
| Saturday Nov 7, 2020 |  | Clemson Tigers Notre Dame Stadium, South Bend, IN | 7:30 PM ET NBC | Won 47-40 2OT |
| Saturday Nov 14, 2020 |  | at Boston College Eagles Alumni Stadium, Chestnut Hill, MA | 3:30 PM ET ABC | Won 45-31 |
| Friday Nov 27, 2020 |  | at North Carolina Tar Heels Kenan Memorial Stadium, Chapel Hill, NC | 3:30 PM ET ABC | Won 31-17 |
| Saturday Dec 5, 2020 |  | Syracuse Orange Notre Dame Stadium, South Bend, IN | 2:30 PM ET NBC | Won 45-21 |
| Saturday Dec 19, 2020 | | Clemson Tigers ACC Championship Bank of America Stadium, Charlotte, NC | 4:00 PM ET ABC | Lost 34-10 |
| Friday Jan 1, 2021 |  | Alabama Crimson Tide Rose Bowl AT&T Stadium, Arlington, TX | 4:00 PM ET ESPN | Lost 31-14 |
