| Date | Opponent | Time/TV | Tickets | |
| Monday Sep 2, 2019 |  | at Louisville Cardinals Cardinal Stadium, Louisville, KY | 8:00 PM ET ESPN | Won 35-17 |
| Saturday Sep 7, 2019 | Bye Week | | ||
| Saturday Sep 14, 2019 |  | New Mexico Lobos Notre Dame Stadium, South Bend, IN | 2:30 PM ET NBC | Won 66-14 |
| Saturday Sep 21, 2019 |  | at Georgia Bulldogs Sanford Stadium, Athens, GA | 8:00 PM ET CBS | Lost 23-17 |
| Saturday Sep 28, 2019 |  | Virginia Cavaliers Notre Dame Stadium, South Bend, IN | 3:30 PM ET NBC | Won 35-20 |
| Saturday Oct 5, 2019 |  | Bowling Green Falcons Notre Dame Stadium, South Bend, IN | 3:30 PM ET NBC | Won 52-0 |
| Saturday Oct 12, 2019 |  | USC Trojans Notre Dame Stadium, South Bend, IN | 7:30 PM ET NBC | Won 30-27 |
| Saturday Oct 19, 2019 | Bye Week | | ||
| Saturday Oct 26, 2019 |  | at Michigan Wolverines Michigan Stadium, Ann Arbor, MI | 7:30 PM ET ABC | Lost 45-14 |
| Saturday Nov 2, 2019 |  | Virginia Tech Hokies Notre Dame Stadium, South Bend, IN | 2:30 PM ET NBC | Won 21-20 |
| Saturday Nov 9, 2019 |  | at Duke Blue Devils Wallace Wade Stadium, Durham, NC | 7:30 PM ET ACCN | Won 38-7 |
| Saturday Nov 16, 2019 |  | Navy Midshipmen Notre Dame Stadium, South Bend, IN | 2:30 PM ET NBC | Won 52-20 |
| Saturday Nov 23, 2019 |  | Boston College Eagles Notre Dame Stadium, South Bend, IN | 2:30 PM ET NBC | Won 40-7 |
| Saturday Nov 30, 2019 |  | at Stanford Cardinal Stanford Stadium, Stanford, CA | 4:00 PM ET FOX | Won 45-24 |
| Saturday Dec 28, 2019 |  | Camping World Bowl Iowa State Cyclones Camping World Stadium, Orlando, FL | 12:00 PM ET ABC | Won 33-9 |
