| Date | Opponent | Time/TV | Tickets | |
| Saturday Sep 1, 2018 |  | Michigan Wolverines Notre Dame Stadium, South Bend, IN | 7:30PM ET NBC | Won 24-17 |
| Saturday Sep 8, 2018 |  | Ball State Cardinals Notre Dame Stadium, South Bend, IN | 3:30PM ET NBC | Won 24-16 |
| Saturday Sep 15, 2018 |  | Vanderbilt Commodores Notre Dame Stadium, South Bend, IN | 2:30PM ET NBC | Won 22-17 |
| Saturday Sep 22, 2018 |  | at Wake Forest Demon Deacons BB&T Field, Winston-Salem, NC | 12:00 PM ET ABC | Won 56-27 |
| Saturday Sep 29, 2018 |  | Stanford Cardinal Notre Dame Stadium, South Bend, IN | 7:30PM ET NBC | Won 38-17 |
| Saturday Oct 6, 2018 |  | at Virginia Tech Hokies Lane Stadium, Blacksburg, VA | Time: TBA TV: TBA | Won 45-23 |
| Saturday Oct 13, 2018 |  | Pittsburgh Panthers Notre Dame Stadium, South Bend, IN | 2:30PM ET NBC | Won 19-14 |
| Saturday Oct 20, 2018 | Bye Week | |||
| Saturday Oct 27, 2018 |  | Navy Midshipmen Qualcomm Stadium, San Diego, CA | 8:00 PM ET CBS | Won 44-22 |
| Saturday Nov 3, 2018 |  | at Northwestern Wildcats Ryan Field, Evanston, IL | Time: TBA TV: TBA | Won 31-21 |
| Saturday Nov 10, 2018 |  | Florida State Seminoles Notre Dame Stadium, South Bend, IN | 7:30PM ET NBC | Won 42-13 |
| Saturday Nov 17, 2018 |  | Syracuse Orange Yankee Stadium, Bronx, NY | 2:30PM ET NBC | Won 36-3 |
| Saturday Nov 24, 2018 |  | at USC Trojans LA Memorial Coliseum, Los Angeles, CA | Time: TBA TV: TBA | Won 24-17 |
| Saturday Dec 29, 2018 |  | vs Clemson Cotton Bowl Classic Playoff AT&T Stadium, Arlington, TX | 4:00 PM ET ESPN | Lost 30-3 |
