| Date | Opponent | Time/TV | Tickets | |
| Sunday Aug 31, 2025 |  | at Miami Hurricanes Hard Rock Stadium, Miami Gardens, FL | 7:30 PM ET ABC ESPN+ | View Tickets |
| Saturday Sep 6, 2025 | Bye Week | |||
| Saturday Sep 13, 2025 |  | Texas A&M Aggies Notre Dame Stadium, South Bend, IN | Time: TBA TV: TBA | View Tickets |
| Saturday Sep 20, 2025 |  | Purdue Boilermakers Notre Dame Stadium, South Bend, IN | Time: TBA TV: TBA | View Tickets |
| Saturday Sep 27, 2025 |  | at Arkansas Razorbacks DWR Razorback Stadium, Fayetteville, AR | Time: TBA TV: TBA | View Tickets |
| Saturday Oct 4, 2025 |  | Boise State Broncos Notre Dame Stadium, South Bend, IN | Time: TBA TV: TBA | View Tickets |
| Saturday Oct 11, 2025 |  | NC State Wolfpack Notre Dame Stadium, South Bend, IN | Time: TBA TV: TBA | View Tickets |
| Saturday Oct 18, 2025 |  | USC Trojans Notre Dame Stadium, South Bend, IN | Time: TBA TV: TBA | View Tickets |
| Saturday Oct 25, 2025 | Bye Week | |||
| Saturday Nov 1, 2025 |  | at Boston College Eagles Alumni Stadium, Chestnut Hill, MA | Time: TBA TV: TBA | View Tickets |
| Saturday Nov 8, 2025 |  | Navy Midshipmen Notre Dame Stadium, South Bend, IN | Time: TBA TV: TBA | View Tickets |
| Saturday Nov 15, 2025 |  | at Pittsburgh Panthers Acrisure Stadium, Pittsburgh, PA | Time: TBA TV: TBA | View Tickets |
| Saturday Nov 22, 2025 |  | Syracuse Orange Notre Dame Stadium, South Bend, IN | Time: TBA TV: TBA | View Tickets |
| Saturday Nov 29, 2025 |  | at Stanford Cardinal Stanford Stadium, Stanford, CA | Time: TBA TV: TBA | View Tickets |
