| Date | Opponent | Time/TV | Tickets | |
| Saturday Sep. 3, 2022 |  | at Ohio State Buckeyes Ohio Stadium, Columbus, OH | 7:30 PM ET ABC | Lost 21-10 |
| Saturday Sep. 10, 2022 |  | Marshall Thundering Herd Notre Dame Stadium, South Bend, IN | 2:30 PM ET NBC | Lost 26-21 |
| Saturday Sep. 17, 2022 |  | California Golden Bears Notre Dame Stadium, South Bend, IN | 2:30 PM ET NBC | Won 24-17 |
| Saturday Sep. 24, 2022 |  | at North Carolina Tar Heels Kenan Memorial Stadium, Chapel Hill, NC | 3:30 PM ET ABC | Won 45-32 |
| Saturday Oct. 1, 2022 | Bye Week | |||
| Saturday Oct. 8, 2022 |  | BYU Cougars Allegiant Stadium, Las Vegas, NV | 7:30 PM ET NBC | Won 28-20 |
| Saturday Oct. 15, 2022 |  | Stanford Cardinal Notre Dame Stadium, South Bend, IN | 7:30 PM ET NBC | Lost 16-14 |
| Saturday Oct. 22, 2022 |  | UNLV Rebels Notre Dame Stadium, South Bend, IN | 2:30 PM ET Peacock | Won 44-21 |
| Saturday Oct 29, 2022 |  | at Syracuse Orange Carrier Dome, Syracuse, NY | 12:00 PM ET ABC | Won 41-24 |
| Saturday Nov. 5, 2022 |  | Clemson Tigers Notre Dame Stadium, South Bend, IN | 7:30 PM ET NBC | Won 35-14 |
| Saturday Nov. 12, 2022 |  | Navy Midshipmen M&T Bank Stadium, Baltimore, MD | 12:00 PM ET ABC ESPN | Won 35-32 |
| Saturday Nov 19, 2022 |  | Boston College Eagles Notre Dame Stadium, South Bend, IN | 2:30 PM ET NBC | Won 44-0 |
| Saturday Nov. 26, 2022 |  | at USC Trojans LA Memorial Coliseum, Los Angeles, CA | 7:30 PM ET ABC | Lost 38-27 |
| Friday Dec 30, 2022 |  | South Carolina Gamecocks TaxSlayer Gator Bowl TIAA Bank Field, Jacksonville, FL | 3:30 PM ET ESPN | Won 45-38 |
