| Date | Opponent | Time/TV | Tickets | |
| Saturday Sept. 5, 2015 |  | Texas Longhorns Notre Dame Stadium, Notre Dame, IN | 7:30 PM ET | Won 38-3 |
| Saturday Sept. 12, 2015 |  | Virginia Cavaliers Scott Stadium, Charlottesville, VA | 3:30 PM ET TV | Won 34-27 |
| Saturday Sept. 19, 2015 |  | Georgia Tech Yellow Jackets Notre Dame Stadium, Notre Dame, IN | 3:30 PM ET TV | Won 30-22 |
| Saturday Sept. 26, 2015 |  | UMass Minutemen Notre Dame Stadium, Notre Dame, IN | 3:30 PM ET | Won 62-27 |
| Saturday Oct. 3, 2015 |  | Clemson Tigers Memorial Stadium, Clemson, SC | 8:00 PM ET | Lost 24-22 |
| Saturday Oct. 10, 2015 |  | Navy Midshipmen Notre Dame Stadium, Notre Dame, IN | 3:30 PM ET | Won 41-24 |
| Saturday Oct. 17, 2015 |  | USC Trojans Notre Dame Stadium, Notre Dame, IN | 7:30 PM ET | Won 41-31 |
| Saturday Oct. 24, 2015 | Bye Week | |||
| Saturday Oct. 31, 2015 |  | Temple Owls Lincoln Financial Field, Philadelphia, PA | 8:00 PM ET ABC | Won 24-20 |
| Saturday Nov. 7, 2015 |  | Pittsburgh Panthers Heinz Field, Pittsburgh, PA | 12:00 PM ET ABC | Won 42-30 |
| Saturday Nov. 14, 2015 |  | Wake Forest Demon Deacons Notre Dame Stadium, Notre Dame, IN | 3:30 PM ET | Won 28-7 |
| Saturday Nov. 21, 2015 |  | Boston College Eagles Fenway Park, Boston, MA | 7:30 PM ET | Won 19-16 |
| Saturday Nov. 28, 2015 |  | Stanford Cardinal Stanford Stadium, Stanford, CA | 7:30 PM ET FOX | Lost 38-36 |
| Friday Jan. 01, 2016 |  | Fiesta Bowl Ohio State Buckeyes University Of Phoenix Stadium, Glendale, AZ | 1:00 PM ET ESPN | Lost 44-28 |
